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KMID : 0606320040210010067
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.21 No. 1 p.67 ~ p.72
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Effects of Dextromethorphan on the proliferation and cytokines production of mouse splenocytes
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Pyo Myoung-Yun
Hwang Yoo-Kyung
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Abstract
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Dextromethorphan hydrobromide (DXM) has been widely used as a nonopioid antitussive drug and is a psychotropic drug since 2003 in our country. This study was performed to investigate the immunotoxicity of DXM by assay of splenocytes proliferation (SP) and induction of cytokine (IFN-γ, IL-4) in vitro. When mouse splenocytes were exposed to various concentration of DXM (0.001,0.01,0.1,1,10,100μM) and cultured with T cell mitogen (Con A) or B cell mitogen (LPS), SP to Ccn A and LPS were significantly decreased at high concentration (100μM). When compared with controls. When splenocytes were cultured with DXM in the presence of Con A, levels of IFN-γ in culture supernatant were slightly decreased at low concentration, and significantly decreased at high concentration (100μM). DXM also suppressed IL-4 secretion significantly at 100μM, however, increased the production of IL-4 at lower concentration when compared with control group. This study provides the substantial evidence on DXM-induced alternation in cell-mediated and humoral immunity. resse
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